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KMID : 0900920030270010001
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Korean journal of Animal Reproduction
2003 Volume.27 No. 1 p.1 ~ p.7
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Studies on the Production of Transgenic Rabbits with Growth Hormone Receptor and IGF-1 Receptor Genes
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Kim Hyun-Joo
Kang Hyee-Sung
Choi Hwa-Sik
Lim Kyung-Sun
Jin Dong-Il
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Abstract
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Transgenic rabbits were produced by DNA microinjection using growth hormone receptor (GHR) and IGF-1 receptor (IGF-1R) genes fused to metallothionein(MT) promoter. The overall efficiencies for production of transgenic rabbits were 3.2% and 3.1% for GHR and IGF-lR genes, respectively. Founder rabbits transmitted transgenes to their progenies through medelian fashion. Growth rate of GHR and IGF-lR transgenic rabbits was significantly faster than that of non-transgenic rabbits. Transgenic rabbits grew large. (25% and 15% increase in body weight of GHR and IGF-lR transgenic rabbits, respectively) than non-transgenic rabbits and organ weight of transgenic rabbits increased, suggesting that GHR and IGF-1R genes affects growth rates in transgenic rabbits.
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KEYWORD
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Transgenic rabbits, Growth hormone receptor gene, ICF-1 receptor gene, Growth rate
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